Doktorandin medizinale Chemie / molekulare Biochemie

Synthese und biologische Testung von Histon-Deacetylase-Inhibitoren für eine wirksamere CAR-T-Zelltherapie

Synthesis and Biological Evaluation of Histone Deacetalyse Inhibitors for more effective CAR-T Cell Therapy

Abstract: Chimeric antigen receptor (CAR) T cells are a form of cancer immunotherapy in which a patient's T cells are genetically modified to specifically target and kill cancer cells. The use of small molecule activators for CAR T cells is an emerging area of research aimed at increasing the efficacy and versatility of CAR T cell therapies. A well-known class of small molecules are histone deacetylase inhibitors (HDACi). HDACi can modify tumor cells to make them more susceptible to CAR-T cell-mediated lysis. The objectives of this research project are to synthesize novel HDAC inhibitors and test their biological activity using in vitro enzyme assays. In addition, the influence of HDACi on specific cancer cell lines will be tested in vivo.